Prescription Required.Why?
A sulfonylurea drug that stimulates the pancreas to release more insulin.
A biguanide that improves insulin sensitivity and reduces glucose production by the liver.
Type 2 diabetes mellitus when diet and exercise alone are not enough to control blood sugar levels.
Often used in patients who are overweight or obese with type 2 diabetes.
Glibenclamide increases insulin secretion from the pancreas, while metformin enhances insulin sensitivity in peripheral tissues and reduces hepatic glucose production. The combined effect leads to improved blood glucose control.
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Dosage should be determined by a healthcare professional based on individual needs and response.
Typically started at a low dose and gradually increased as needed.
Usually taken with meals to minimize gastrointestinal side effects.
Never adjust the dosage without consulting your doctor.
Lactic acidosis (rare but serious, more likely in patients with kidney impairment).
Hypoglycemia (low blood sugar): Symptoms include sweating, tremor, dizziness, palpitations, confusion, and seizures.
Gastrointestinal upset (nausea, vomiting, diarrhea, abdominal pain).
Weight gain (especially with glibenclamide).
Allergic reactions (rash, itching, swelling).
Alcohol can increase the risk of hypoglycemia and lactic acidosis. Limit alcohol intake.
Hypoglycemia can impair cognitive function and reaction time. Avoid driving or operating machinery if experiencing hypoglycemic symptoms.
Generally not recommended during pregnancy or breastfeeding. Consult your doctor.
Not typically used in children.
Dose adjustment or contraindicated in patients with severe kidney disease due to increased risk of lactic acidosis.
Use with caution in patients with liver disease. Regular monitoring of liver function may be necessary.
Your doctor or pharmacist
The medication's package insert
Reputable medical websites (e.g., FDA, NHS, etc.)
